完整後設資料紀錄
DC 欄位語言
dc.contributor.authorHuang, Chien-Feng Jr
dc.contributor.authorLin, Yu-Feng Jr
dc.contributor.authorTseng, Vincent S. Jr
dc.date.accessioned2011-01-26T01:05:10Z
dc.date.accessioned2020-05-18T03:10:40Z-
dc.date.available2011-01-26T01:05:10Z
dc.date.available2020-05-18T03:10:40Z-
dc.date.issued2011-01-26T01:05:10Z
dc.date.submitted2010-12-16
dc.identifier.urihttp://dspace.lib.fcu.edu.tw/handle/2377/29969-
dc.description.abstractOne of the major challenges in systems biology today is to devise robust methods of interpreting data concerning the expression levels of the genes in an organism in a way that will shed light on the collective interactions between multiple genes and their products. The ability to better understand and predict the structures and actions of complex biological systems is of significant importance to modern drug discovery as well as our understanding of the mechanisms behind an organism’s ability to react to its environment. In this paper we present a study for robust biological pathway construction through an agent-based methodology-probability collectives multi-agent systems (PCMAS). This technique relies on the search of particular seed nodes by probability collectives to construct biological networks based on various sets of interaction information and gene expression data. As an application, expression data of ofloxacin response in M. tuberculosis is used to build response networks. We then demonstrate how this approach provides robust prediction of response networks to facilitate drug target identification on systems-level.
dc.description.sponsorshipNational Cheng Kung University,Tainan
dc.format.extent6p.
dc.relation.ispartofseries2010 ICS會議
dc.subjectBiological networks
dc.subjectMycobacterium tuberculosis probability collectives multi-agent systems
dc.subjectrobust prediction
dc.subject.otherBiomedical Informatics
dc.titleAgent-based Optimization of Biological Response Networks
分類:2010年 ICS 國際計算機會議(如需查看全文,請連結至IEEE Xplore網站)

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。